Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation

The E571K mutation of CRM1 is highly prevalent in some cancers, but its mechanism of tumorigenesis is unclear. Glu571 of CRM1 is located in its nuclear export signal (NES)-binding groove, suggesting that binding of select NESs may be altered. We generated HEK 293 cells with either monoallelic CRM1WT...

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Detalles Bibliográficos
Autores principales: Baumhardt, Jordan M., Walker, Janek S., Lee, Yoonji, Shakya, Binita, Brautigam, Chad A., Lapalombella, Rosa, Grishin, Nick, Chook, Yuh Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525811/
https://www.ncbi.nlm.nih.gov/pubmed/32520643
http://dx.doi.org/10.1091/mbc.E20-04-0233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525811/
https://www.ncbi.nlm.nih.gov/pubmed/32520643
http://dx.doi.org/10.1091/mbc.E20-04-0233

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