Cargando…

HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer

The positive transcription elongation factor b (P-TEFb), composed of CDK9 and cyclin T, stimulates transcriptional elongation by RNA polymerase (Pol) II and regulates cell growth and differentiation. Recently, we demonstrated that P-TEFb also controls the expression of EMT regulators to promote brea...

Descripción completa

Detalles Bibliográficos
Autores principales: Shao, Hengyi, Zhu, Qingwei, Lu, Huasong, Chang, Amanda, Gao, Carol, Zhou, Qiang, Luo, Kunxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525814/
https://www.ncbi.nlm.nih.gov/pubmed/32520633
http://dx.doi.org/10.1091/mbc.E19-12-0704