KDM5c Promotes Colon Cancer Cell Proliferation Through the FBXW7-c-Jun Regulatory Axis

KDM5c is a histone demethylase that specifically demethylates trimethylated and dimethylated H3 Lys-4 to play a central role in transcriptional repression. C-Jun is a proto-oncogene and promotes cell proliferation when ectopically accumulated, but can be ubiquitinated by SCF (FBXW7), leading to its...

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Detalles Bibliográficos
Autores principales: Lin, Haishan, Ma, Nina, Zhao, Lei, Yang, Guowei, Cao, Bangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526003/
https://www.ncbi.nlm.nih.gov/pubmed/33042830
http://dx.doi.org/10.3389/fonc.2020.535449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526003/
https://www.ncbi.nlm.nih.gov/pubmed/33042830
http://dx.doi.org/10.3389/fonc.2020.535449

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