Cargando…

Retargeting azithromycin analogues to have dual-modality antimalarial activity

BACKGROUND: Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies to rapidly kill Plasmodium spp. malaria parasites is urgently needed. Azithromycin is a clinically used macrolide antibiotic proposed as a partner dru...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burns, Amy L., Sleebs, Brad E., Siddiqui, Ghizal, De Paoli, Amanda E., Anderson, Dovile, Liffner, Benjamin, Harvey, Richard, Beeson, James G., Creek, Darren J., Goodman, Christopher D., McFadden, Geoffrey I., Wilson, Danny W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526119/ https://www.ncbi.nlm.nih.gov/pubmed/32993629 http://dx.doi.org/10.1186/s12915-020-00859-4

Ejemplares similares

Targeting malaria parasites with novel derivatives of azithromycin
por: Burns, Amy L., et al.
Publicado: (2022)

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion
por: Giannangelo, Carlo, et al.
Publicado: (2020)

Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells
por: Siddiqui, Ghizal, et al.
Publicado: (2022)

Current and emerging target identification methods for novel antimalarials
por: Challis, Matthew P., et al.
Publicado: (2022)

Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum
por: Wilson, Danny W, et al.
Publicado: (2015)

Red Blood Cell BCL-x(L) Is Required for Plasmodium falciparum Survival: Insights into Host-Directed Malaria Therapies
por: Boulet, Coralie, et al.
Publicado: (2022)

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
por: Tjhin, Erick T., et al.
Publicado: (2018)

Cell biological analysis reveals an essential role for Pfcerli2 in erythrocyte invasion by malaria parasites
por: Liffner, Benjamin, et al.
Publicado: (2022)

Antimalarial Properties of Simplified Kalihinol Analogues
por: Daub, Mary Elisabeth, et al.
Publicado: (2017)

Retargeting of Viruses to Generate Oncolytic Agents
por: Verheije, M. H., et al.
Publicado: (2012)

Retargeting the management of hypercholesterolemia – focus on evolocumab
por: Colletti, Alessandro, et al.
Publicado: (2016)

Endothelial Retargeting of AAV9 In Vivo
por: Bozoglu, Tarik, et al.
Publicado: (2022)

A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum–infected red blood cell proteome
por: Siddiqui, Ghizal, et al.
Publicado: (2022)

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties
por: Urgin, Karène, et al.
Publicado: (2017)

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials
por: Cui, Huaqing, et al.
Publicado: (2012)

Synthesis and Antimalarial Evaluation of Halogenated Analogues of Thiaplakortone A
por: Egbewande, Folake A., et al.
Publicado: (2023)

Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
por: Burns, Amy L, et al.
Publicado: (2019)

Retargeting Strategies for Oncolytic Herpes Simplex Viruses
por: Campadelli-Fiume, Gabriella, et al.
Publicado: (2016)

Retargeted adenoviruses for radiation-guided gene delivery
por: Kaliberov, S A, et al.
Publicado: (2016)

Tools for retargeting proteins within Aspergillus nidulans
por: Suresh, Subbulakshmi, et al.
Publicado: (2017)

Unprecedented Epimerization of an Azithromycin Analogue: Synthesis, Structure and Biological Activity of 2′-Dehydroxy-5″-Epi-Azithromycin
por: Kragol, Goran, et al.
Publicado: (2022)

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
por: Richardson, Lachlan W., et al.
Publicado: (2022)

Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents
por: Wang, Jiayi, et al.
Publicado: (2014)

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane
por: Blank, Brian R., et al.
Publicado: (2017)

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum
por: Krollenbrock, Alina, et al.
Publicado: (2021)

Retargeting Adenoviral Vectors to Improve Gene Transfer into Tumors
por: Hogg, Richard T., et al.
Publicado: (2010)

Impact of the addition of azithromycin to antimalarials used for seasonal malaria chemoprevention on antimicrobial resistance of Streptococcus pneumoniae
por: Hema‐Ouangraoua, Soumeya, et al.
Publicado: (2019)

Maximizing antimalarial efficacy and the importance of dosing strategies
por: Beeson, James G, et al.
Publicado: (2015)

C−H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity
por: O' Donovan, Daniel H., et al.
Publicado: (2018)

Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review
por: Parhizgar, Arezoo Rafiee, et al.
Publicado: (2017)

Image content retargeting: maintaining color, tone, and spatial consistency
por: Artusi, Alessandro, et al.
Publicado: (2016)

Improved content aware scene retargeting for retinitis pigmentosa patients
por: Al-Atabany, Walid I, et al.
Publicado: (2010)

Retargeted Clostridial Neurotoxins as Novel Agents for Treating Chronic Diseases
por: Yeh, Felix L., et al.
Publicado: (2011)

Retargeting transposon insertions by the adeno-associated virus Rep protein
por: Ammar, Ismahen, et al.
Publicado: (2012)

Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol
por: Pavlik, Benjamin J., et al.
Publicado: (2016)

An image retrieval framework for real-time endoscopic image retargeting
por: Ye, Menglong, et al.
Publicado: (2017)

RNA-guided retargeting of Sleeping Beauty transposition in human cells
por: Kovač, Adrian, et al.
Publicado: (2020)

Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
por: Kloehn, Joachim, et al.
Publicado: (2020)

3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents
por: Hadni, Hanine, et al.
Publicado: (2020)

Inducible expression of coding and inhibitory RNAs from retargetable genomic loci
por: Weidenfeld, Ina, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_g0u6lj3igpef0g4gola4gn4l52