The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia

BACKGROUND: After High-Dose Methotrexate (HD-MTX), folinic acid rescue therapy (Leucovorin) is administered to reduce side effects in pediatric acute lymphoblastic leukemia (ALL) patients. Leucovorin and MTX are structural analogues, possibly competing for cellular transport and intracellular metabo...

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Detalles Bibliográficos
Autores principales: Oosterom, N., Fiocco, M., Kloos, R. Q. H., van der Sluis, I. M., Pieters, R., van Zelst, B. D., Smith, D. E. C., van den Heuvel-Eibrink, M. M., de Jonge, R., Heil, S. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526241/
https://www.ncbi.nlm.nih.gov/pubmed/32998716
http://dx.doi.org/10.1186/s12885-020-07422-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526241/
https://www.ncbi.nlm.nih.gov/pubmed/32998716
http://dx.doi.org/10.1186/s12885-020-07422-y

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