ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis

Orphan nuclear receptor estrogen-related receptor γ (ERRγ) stimulates bile acid production; however, the role and the regulatory mechanism of ERRγ in cholestatic liver disease are largely unknown. This study identifies that Sirt6 is a deacetylase of ERRγ and suggests a potentially novel mechanism by...

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Detalles Bibliográficos
Autores principales: Hao, Lihua, Bang, In Hyuk, Wang, Jie, Mao, Yuancheng, Yang, Jae Do, Na, Soon-Young, Seo, Jeong Kon, Choi, Hueng-Sik, Bae, Eun Ju, Park, Byung-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526444/
https://www.ncbi.nlm.nih.gov/pubmed/32701506
http://dx.doi.org/10.1172/jci.insight.137566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526444/
https://www.ncbi.nlm.nih.gov/pubmed/32701506
http://dx.doi.org/10.1172/jci.insight.137566

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