PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

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New strategies are needed to enhance the efficacy of anti–programmed cell death protein antibody (anti–PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of chloroquine derivatives like hydroxychloroquine (HCQ), enhances the antitumor efficacy of an...

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Detalles Bibliográficos
Autores principales: Sharma, Gaurav, Ojha, Rani, Noguera-Ortega, Estela, Rebecca, Vito W., Attanasio, John, Liu, Shujing, Piao, Shengfu, Lee, Jennifer J., Nicastri, Michael C., Harper, Sandra L., Ronghe, Amruta, Jain, Vaibhav, Winkler, Jeffrey D., Speicher, David W., Mastio, Jerome, Gimotty, Phyllis A., Xu, Xiaowei, Wherry, E. John, Gabrilovich, Dmitry I., Amaravadi, Ravi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526447/
https://www.ncbi.nlm.nih.gov/pubmed/32780726
http://dx.doi.org/10.1172/jci.insight.133225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526447/
https://www.ncbi.nlm.nih.gov/pubmed/32780726
http://dx.doi.org/10.1172/jci.insight.133225

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