High microbiota reactivity of adult human intestinal IgA requires somatic mutations

The gut is home to the body’s largest population of plasma cells. In healthy individuals, IgA is the dominating isotype, whereas patients with inflammatory bowel disease also produce high concentrations of IgG. In the gut lumen, secretory IgA binds pathogens and toxins but also the microbiota. Howev...

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Detalles Bibliográficos
Autores principales: Kabbert, Johanna, Benckert, Julia, Rollenske, Tim, Hitch, Thomas C.A., Clavel, Thomas, Cerovic, Vuk, Wardemann, Hedda, Pabst, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526496/
https://www.ncbi.nlm.nih.gov/pubmed/32640466
http://dx.doi.org/10.1084/jem.20200275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526496/
https://www.ncbi.nlm.nih.gov/pubmed/32640466
http://dx.doi.org/10.1084/jem.20200275

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