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Epigenetic silencing of CD4 expression in nonpathogenic SIV infection in African green monkeys
African green monkeys (AGMs) are natural hosts of SIV that postthymically downregulate CD4 to maintain a large population of CD4(–)CD8aa(+) virus-resistant cells with Th functionality, which can result in AGMs becoming apparently cured of SIV(agm) infection. To understand the mechanisms of this proc...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526541/ https://www.ncbi.nlm.nih.gov/pubmed/32841214 http://dx.doi.org/10.1172/jci.insight.139043 |