PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb

Compromised muscle mitochondrial metabolism is a hallmark of peripheral arterial disease, especially in patients with the most severe clinical manifestation — critical limb ischemia (CLI). We asked whether inflexibility in metabolism is critical for the development of myopathy in ischemic limb muscl...

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Detalles Bibliográficos
Autores principales: Ryan, Terence E., Schmidt, Cameron A., Tarpey, Michael D., Amorese, Adam J., Yamaguchi, Dean J., Goldberg, Emma J., Iñigo, Melissa M.R., Karnekar, Reema, O’Rourke, Allison, Ervasti, James M., Brophy, Patricia, Green, Thomas D., Neufer, P. Darrell, Fisher-Wellman, Kelsey, Spangenburg, Espen E., McClung, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526546/
https://www.ncbi.nlm.nih.gov/pubmed/32841216
http://dx.doi.org/10.1172/jci.insight.139628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526546/
https://www.ncbi.nlm.nih.gov/pubmed/32841216
http://dx.doi.org/10.1172/jci.insight.139628

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