Cargando…
PFKFB3-mediated glycolysis rescues myopathic outcomes in the ischemic limb
Compromised muscle mitochondrial metabolism is a hallmark of peripheral arterial disease, especially in patients with the most severe clinical manifestation — critical limb ischemia (CLI). We asked whether inflexibility in metabolism is critical for the development of myopathy in ischemic limb muscl...
Autores principales: | Ryan, Terence E., Schmidt, Cameron A., Tarpey, Michael D., Amorese, Adam J., Yamaguchi, Dean J., Goldberg, Emma J., Iñigo, Melissa M.R., Karnekar, Reema, O’Rourke, Allison, Ervasti, James M., Brophy, Patricia, Green, Thomas D., Neufer, P. Darrell, Fisher-Wellman, Kelsey, Spangenburg, Espen E., McClung, Joseph M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526546/ https://www.ncbi.nlm.nih.gov/pubmed/32841216 http://dx.doi.org/10.1172/jci.insight.139628 |
Ejemplares similares
-
Effects of fasting on isolated murine skeletal muscle contractile function during acute hypoxia
por: Schmidt, Cameron A., et al.
Publicado: (2020) -
Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function
por: Tarpey, Michael D., et al.
Publicado: (2018) -
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet–Fed Mice
por: Ryan, Terence E., et al.
Publicado: (2016) -
Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle
por: Amorese, Adam J, et al.
Publicado: (2023) -
Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation
por: Pereyra, Andrea S., et al.
Publicado: (2022)