Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation

Age-associated systemic, chronic inflammation is partially attributed to increased self-autoreactivity, resulting from disruption of central tolerance in the aged, involuted thymus. This involution causally results from gradually decreased expression of the transcription factor FOXN1 in thymic epith...

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Detalles Bibliográficos
Autores principales: Oh, Jiyoung, Wang, Weikan, Thomas, Rachel, Su, Dong-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526556/
https://www.ncbi.nlm.nih.gov/pubmed/32790650
http://dx.doi.org/10.1172/jci.insight.140313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526556/
https://www.ncbi.nlm.nih.gov/pubmed/32790650
http://dx.doi.org/10.1172/jci.insight.140313

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