Cargando…
All-atom simulation of the HET-s prion replication
Prions are self-replicative protein particles lacking nucleic acids. Originally discovered for causing infectious neurodegenerative disorders, they have also been found to play several physiological roles in a variety of species. Functional and pathogenic prions share a common mechanism of replicati...
Autores principales: | Terruzzi, Luca, Spagnolli, Giovanni, Boldrini, Alberto, Requena, Jesús R., Biasini, Emiliano, Faccioli, Pietro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526898/ https://www.ncbi.nlm.nih.gov/pubmed/32946455 http://dx.doi.org/10.1371/journal.pcbi.1007922 |
Ejemplares similares
-
Full atomistic model of prion structure and conversion
por: Spagnolli, Giovanni, et al.
Publicado: (2019) -
The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility
por: Seuring, Carolin, et al.
Publicado: (2012) -
The Compelling
Demand for an Effective PrP(C)-Directed Therapy against
Prion Diseases
por: Astolfi, Andrea, et al.
Publicado: (2020) -
Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin
por: Kihn, Kyle, et al.
Publicado: (2022) -
Pharmacological inactivation of the prion protein by targeting a folding intermediate
por: Spagnolli, Giovanni, et al.
Publicado: (2021)