Capturing cell type-specific chromatin compartment patterns by applying topic modeling to single-cell Hi-C data

Single-cell Hi-C (scHi-C) interrogates genome-wide chromatin interaction in individual cells, allowing us to gain insights into 3D genome organization. However, the extremely sparse nature of scHi-C data poses a significant barrier to analysis, limiting our ability to tease out hidden biological inf...

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Detalles Bibliográficos
Autores principales: Kim, Hyeon-Jin, Yardımcı, Galip Gürkan, Bonora, Giancarlo, Ramani, Vijay, Liu, Jie, Qiu, Ruolan, Lee, Choli, Hesson, Jennifer, Ware, Carol B., Shendure, Jay, Duan, Zhijun, Noble, William Stafford
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526900/
https://www.ncbi.nlm.nih.gov/pubmed/32946435
http://dx.doi.org/10.1371/journal.pcbi.1008173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526900/
https://www.ncbi.nlm.nih.gov/pubmed/32946435
http://dx.doi.org/10.1371/journal.pcbi.1008173

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