Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium

Cryptic ligand binding sites, which are not evident in the unligated structures, are beneficial in tackling with difficult but attractive drug targets, such as protein-protein interactions (PPIs). However, cryptic sites have thus far not been rationally pursued in the early stages of drug developmen...

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Detalles Bibliográficos
Autores principales: Mizukoshi, Yumiko, Takeuchi, Koh, Tokunaga, Yuji, Matsuo, Hitomi, Imai, Misaki, Fujisaki, Miwa, Kamoshida, Hajime, Takizawa, Takeshi, Hanzawa, Hiroyuki, Shimada, Ichio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527212/
https://www.ncbi.nlm.nih.gov/pubmed/32998885
http://dx.doi.org/10.1126/sciadv.abd0480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527212/
https://www.ncbi.nlm.nih.gov/pubmed/32998885
http://dx.doi.org/10.1126/sciadv.abd0480

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