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Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium
Cryptic ligand binding sites, which are not evident in the unligated structures, are beneficial in tackling with difficult but attractive drug targets, such as protein-protein interactions (PPIs). However, cryptic sites have thus far not been rationally pursued in the early stages of drug developmen...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527212/ https://www.ncbi.nlm.nih.gov/pubmed/32998885 http://dx.doi.org/10.1126/sciadv.abd0480 |