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Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons
Prion diseases are caused by PrP(Sc), a self-replicating pathologically misfolded protein that exerts toxicity predominantly in the brain. The administration of PrP(Sc) causes a robust, reproducible and specific disease manifestation. Here, we have applied a combination of translating ribosome affin...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527237/ https://www.ncbi.nlm.nih.gov/pubmed/32960170 http://dx.doi.org/10.7554/eLife.62911 |