Monoclonal antibody stability can be usefully monitored using the excitation-energy-dependent fluorescence edge-shift

Among the major challenges in the development of biopharmaceuticals are structural heterogeneity and aggregation. The development of a successful therapeutic monoclonal antibody (mAb) requires both a highly active and also stable molecule. Whilst a range of experimental (biophysical) approaches exis...

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Detalles Bibliográficos
Autores principales: Knight, Michael J., Woolley, Rachel E., Kwok, Anthony, Parsons, Stuart, Jones, Hannah B. L., Gulácsy, Christina E., Phaal, Polly, Kassaar, Omar, Dawkins, Kieran, Rodriguez, Elizabeth, Marques, Andreia, Bowsher, Leo, Wells, Stephen A., Watts, Andrew, vandenElsen, Jean M. H., Turner, Alison, O'Hara, John, Pudney, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527260/
https://www.ncbi.nlm.nih.gov/pubmed/32869839
http://dx.doi.org/10.1042/BCJ20200580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527260/
https://www.ncbi.nlm.nih.gov/pubmed/32869839
http://dx.doi.org/10.1042/BCJ20200580

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