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Valproic acid upregulates the expression of the p75NTR/sortilin receptor complex to induce neuronal apoptosis

The antiepileptic and mood stabilizer agent valproic acid (VPA) has been shown to exert anti-tumour effects and to cause neuronal damage in the developing brain through mechanisms not completely understood. In the present study we show that prolonged exposure of SH-SY5Y and LAN-1 human neuroblastoma...

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Detalles Bibliográficos
Autores principales: Dedoni, Simona, Marras, Luisa, Olianas, Maria C., Ingianni, Angela, Onali, Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527367/
https://www.ncbi.nlm.nih.gov/pubmed/32712736
http://dx.doi.org/10.1007/s10495-020-01626-0