Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione

Cell therapies such as chimeric-antigen receptor (CAR) T-cells and NK cells are cutting-edge methods for treating cancer and other diseases. There is high interest in optimizing drug treatment regimens to best work together with emerging cell therapies, such as targeting epigenetic enzymes to stimul...

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Detalles Bibliográficos
Autores principales: Bailey, Cavan P., Figueroa, Mary, Gangadharan, Achintyan, Lee, Dean A., Chandra, Joya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527493/
https://www.ncbi.nlm.nih.gov/pubmed/33042135
http://dx.doi.org/10.3389/fimmu.2020.02196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527493/
https://www.ncbi.nlm.nih.gov/pubmed/33042135
http://dx.doi.org/10.3389/fimmu.2020.02196

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