CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes viral preintegration complexes (PICs) to nuclear speckles for...

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Detalles Bibliográficos
Autores principales: Li, Wen, Singh, Parmit K., Sowd, Gregory A., Bedwell, Gregory J., Jang, Sooin, Achuthan, Vasudevan, Oleru, Amarachi V., Wong, Doris, Fadel, Hind J., Lee, KyeongEun, KewalRamani, Vineet N., Poeschla, Eric M., Herschhorn, Alon, Engelman, Alan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527728/
https://www.ncbi.nlm.nih.gov/pubmed/32994325
http://dx.doi.org/10.1128/mBio.02254-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527728/
https://www.ncbi.nlm.nih.gov/pubmed/32994325
http://dx.doi.org/10.1128/mBio.02254-20

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