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The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators
Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and aged mice. Transcriptome and methylome changes...
Autores principales: | Bou Sleiman, Maroun, Jha, Pooja, Houtkooper, Riekelt, Williams, Robert W., Wang, Xu, Auwerx, Johan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527782/ https://www.ncbi.nlm.nih.gov/pubmed/32997995 http://dx.doi.org/10.1016/j.celrep.2020.108203 |
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