The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS

Nucleotide repeat expansions in the C9orf72 gene cause frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Transcribed repeat RNA accumulates within RNA foci and is also translated into toxic dipeptide repeat proteins (DPR). The mechanism of repeat RNA accumulation, how...

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Detalles Bibliográficos
Autores principales: Kawabe, Yuya, Mori, Kohji, Yamashita, Tomoko, Gotoh, Shiho, Ikeda, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527818/
https://www.ncbi.nlm.nih.gov/pubmed/32830871
http://dx.doi.org/10.15252/embj.2019102700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527818/
https://www.ncbi.nlm.nih.gov/pubmed/32830871
http://dx.doi.org/10.15252/embj.2019102700

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