Cargando…

Inducible TDG knockout models to study epigenetic regulation

Mechanistic and functional studies by gene disruption or editing approaches often suffer from confounding effects like compensatory cellular adaptations generated by clonal selection. These issues become particularly relevant when studying factors directly involved in genetic or epigenetic maintenan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schwarz, Simon D., Grundbacher, Eliane, Hrovat, Alexandra M., Xu, Jianming, Kuśnierczyk, Anna, Vågbø, Cathrine B., Schär, Primo, Schuermann, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2020
Materias:	Method Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527862/ https://www.ncbi.nlm.nih.gov/pubmed/33082936 http://dx.doi.org/10.12688/f1000research.25637.2

Ejemplares similares

Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
por: Weber, Alain R., et al.
Publicado: (2016)

Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2
por: Hardeland, Ulrike, et al.
Publicado: (2007)

Gadd45a promotes DNA demethylation through TDG
por: Li, Zheng, et al.
Publicado: (2015)

Versatile Recombinant SUMOylation System for the Production of SUMO-Modified Protein
por: Weber, Alain R., et al.
Publicado: (2014)

ELF-MF exposure affects the robustness of epigenetic programming during granulopoiesis
por: Manser, Melissa, et al.
Publicado: (2017)

A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA
por: Robertson, Adam B., et al.
Publicado: (2011)

TDG is a novel tumor suppressor of liver malignancies
por: Hassan, Haider M., et al.
Publicado: (2020)

3CAPS – a structural AP–site analogue as a tool to investigate DNA base excision repair
por: Schuermann, David, et al.
Publicado: (2016)

T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif
por: Lucey, Marie J., et al.
Publicado: (2005)

TDG is a pig-specific epigenetic regulator with insensitivity to H3K9 and H3K27 demethylation in nuclear transfer embryos
por: Liu, Xin, et al.
Publicado: (2021)

Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil
por: Kunz, Christophe, et al.
Publicado: (2009)

Generation of medaka gene knockout models by target-selected mutagenesis
por: Taniguchi, Yoshihito, et al.
Publicado: (2006)

JACKS: joint analysis of CRISPR/Cas9 knockout screens
por: Allen, Felicity, et al.
Publicado: (2019)

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription
por: Wang, Guangyu, et al.
Publicado: (2020)

Monitoring of gene knockouts: genome-wide profiling of conditionally essential genes
por: Smith, Lisa K, et al.
Publicado: (2007)

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases
por: Sung, Young Hoon, et al.
Publicado: (2014)

Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging
por: Noreen, Faiza, et al.
Publicado: (2020)

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
por: Schomacher, Lars, et al.
Publicado: (2016)

Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
por: Onodera, Atsushi, et al.
Publicado: (2021)

MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes
por: Wang, Guangyu, et al.
Publicado: (2021)

Knockout of circRNAs by base editing back-splice sites of circularized exons
por: Gao, Xiang, et al.
Publicado: (2022)

Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers
por: Wilson, Gareth A, et al.
Publicado: (2012)

Generation of mouse conditional knockout alleles in one step using the i-GONAD method
por: Shang, Renjie, et al.
Publicado: (2021)

Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells
por: Yan, Jia-Bao, et al.
Publicado: (2020)

The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion
por: Li, Dan, et al.
Publicado: (2020)

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
por: Müller, Udo, et al.
Publicado: (2014)

Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance
por: Sun, Jie, et al.
Publicado: (2015)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
por: Shen, Li, et al.
Publicado: (2013)

Genome-wide analysis reveals TET-and TDG-mediated 5-methylcytosine oxidation dynamics
por: Shen, Li, et al.
Publicado: (2013)

Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG
por: Hashimoto, Hideharu
Publicado: (2014)

Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression
por: Xu, Jinfei, et al.
Publicado: (2017)

TDG Gene Polymorphisms and Their Possible Association with Colorectal Cancer: A Case Control Study
por: Reddy Parine, Narasimha, et al.
Publicado: (2019)

In vivo and in vitro knockout system labelled using fluorescent protein via microhomology-mediated end joining
por: Katayama, Shota, et al.
Publicado: (2019)

p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes
por: Sandoval, Jonathan E., et al.
Publicado: (2020)

COCOA: coordinate covariation analysis of epigenetic heterogeneity
por: Lawson, John T., et al.
Publicado: (2020)

Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase
por: Liu, Yun, et al.
Publicado: (2016)

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
por: Li, Wei, et al.
Publicado: (2014)

Comprehensive histone epigenetics: A mass spectrometry based screening assay to measure epigenetic toxicity
por: Verhelst, Sigrid, et al.
Publicado: (2020)

The epigenetic landscape of Alu repeats delineates the structural and functional genomic architecture of colon cancer cells
por: Jordà, Mireia, et al.
Publicado: (2017)

Assessment of Genotoxicity in Human Cells Exposed to Modulated Electromagnetic Fields of Wireless Communication Devices
por: Schuermann, David, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tbslnv2s18o5iahlsuesol4c6r