Cargando…

Cucurbitacin D Induces G2/M Phase Arrest and Apoptosis via the ROS/p38 Pathway in Capan-1 Pancreatic Cancer Cell Line

Pancreatic cancer has a poor prognosis with a five-year survival rate of less than 10%. Moreover, chemotherapy is mostly rendered ineffective owing to chemotherapy resistance and cytotoxicity. Therefore, the development of effective therapeutic strategies and novel drugs against pancreatic cancer is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Myeong-Sun, Lee, Kangwook, Ku, Jin Mo, Choi, Yu-Jeong, Mok, Kyungyul, Kim, Doori, Cheon, Chunhoo, Ko, Seong-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527894/ https://www.ncbi.nlm.nih.gov/pubmed/33029168 http://dx.doi.org/10.1155/2020/6571674

Ejemplares similares

Cucurbitacin D Overcomes Gefitinib Resistance by Blocking EGF Binding to EGFR and Inducing Cell Death in NSCLCs
por: Hong, Se Hyang, et al.
Publicado: (2020)

Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells
por: Ku, Jin Mo, et al.
Publicado: (2015)

Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes
por: Kim, Hyo In, et al.
Publicado: (2020)

State of the Art and Future Implications of SH003: Acting as a Therapeutic Anticancer Agent
por: Lee, Kangwook, et al.
Publicado: (2022)

Phase I study to evaluate the maximum tolerated dose of the combination of SH003 and docetaxel in patients with solid cancer: A study protocol
por: Cheon, Chunhoo, et al.
Publicado: (2020)

A Phase I Study to Evaluate the Safety of the Herbal Medicine SH003 in Patients With Solid Cancer
por: Cheon, Chunhoo, et al.
Publicado: (2020)

Synergistic effects of natural products in combination with anticancer agents in prostate cancer: A scoping review
por: Cheon, Chunhoo, et al.
Publicado: (2022)

SH003 activates autophagic cell death by activating ATF4 and inhibiting G9a under hypoxia in gastric cancer cells
por: Kim, Tae Woo, et al.
Publicado: (2020)

Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells
por: Kim, Soon Re, et al.
Publicado: (2013)

Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells
por: Kim, Tae Woo, et al.
Publicado: (2018)

Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner
por: Guo, Jiajie, et al.
Publicado: (2014)

Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
por: Kong, Yanjie, et al.
Publicado: (2014)

Pattern identification of lung cancer patients based on body constitution questionnaires (BCQ) and glycoproteomics for precision medicine
por: Cho, Wonryeon, et al.
Publicado: (2019)

Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E
por: Hsu, Y-C, et al.
Publicado: (2014)

Critical enzymes for biosynthesis of cucurbitacin derivatives in watermelon and their biological significance
por: Kim, Young-Cheon, et al.
Publicado: (2020)

Herbal Prescription SH003 Alleviates Docetaxel-Induced Neuropathic Pain in C57BL/6 Mice
por: Lee, Kangwook, et al.
Publicado: (2021)

Investigation of Molecular Mechanisms Involved in Sensitivity to the Anti-Cancer Activity of Costunolide in Breast Cancer Cells
por: Choi, Yu-Jeong, et al.
Publicado: (2023)

Implementing accountable care organizations with integrative medicine in Korean health care system
por: Youn, Bo-Young, et al.
Publicado: (2021)

SH003 reverses drug resistance by blocking signal transducer and activator of transcription 3 (STAT3) signaling in breast cancer cells
por: Seo, Hye-Sook, et al.
Publicado: (2017)

Cucurbitacin E Induces Autophagy-Involved Apoptosis in Intestinal Epithelial Cells
por: Song, Huapei, et al.
Publicado: (2020)

Sipjeondaebo-tang in patients with breast cancer with fatigue: a protocol for a pilot, randomised, double-blind, placebo-controlled, cross-over trial
por: Cheon, Chunhoo, et al.
Publicado: (2018)

Maekmoondong-tang in treatment of postoperative cough in patients with lung cancer: Study protocol for a randomized, double-blind, placebo-controlled, multicenter trial
por: Cheon, Chunhoo, et al.
Publicado: (2018)

Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol
por: Cheon, Chunhoo, et al.
Publicado: (2018)

An updated review of Cucurbitacins and their biological and pharmacological activities
por: Chung, Sun Ok, et al.
Publicado: (2015)

Cucurbitacins: elucidation of their interactions with the cytoskeleton
por: Wang, Xiaojuan, et al.
Publicado: (2017)

Pharmacokinetics and Biological Activity of Cucurbitacins
por: Delgado-Tiburcio, Eugenia Elisa, et al.
Publicado: (2022)

Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic Cells
por: Ishdorj, Ganchimeg, et al.
Publicado: (2011)

Traditional Herbal Formula Taeeumjowi-Tang (TJ001) Inhibits p53-Mutant Prostate Cancer Cells Growth by Activating AMPK-Dependent Pathway
por: Kang, Sooyeon, et al.
Publicado: (2019)

[6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice
por: Kim, Suyong, et al.
Publicado: (2022)

Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells
por: Qu, Yingchun, et al.
Publicado: (2017)

Synthesis of cucurbitacin IIa derivatives with apoptosis-inducing capabilities in human cancer cells
por: Yu, Kun, et al.
Publicado: (2020)

The relationship between spinal pain and temporomandibular joint disorders in Korea: a nationwide propensity score-matched study
por: Kim, Doori, et al.
Publicado: (2019)

Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling
por: Lee, Seung-On, et al.
Publicado: (2021)

Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery
por: Kim, Ahyeon, et al.
Publicado: (2021)

DSGOST regulates resistance via activation of autophagy in gastric cancer
por: Kim, Tae Woo, et al.
Publicado: (2018)

Cucurbitacin E as Inducer of Cell Death and Apoptosis in Human Oral Squamous Cell Carcinoma Cell Line SAS
por: Hung, Chao-Ming, et al.
Publicado: (2013)

The effects of cyclooxygenase-2 gene silencing by siRNA on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of Capan-2 human pancreatic cancer cells
por: ZHONG, YINGQIANG, et al.
Publicado: (2011)

Flow Cytometric Bromodeoxyuridine/DNA Analysis of Hyperthermia and/or Adriamycin for Human Pancreatic Adenocarcinoma Cell Line Capan‐2
por: Nakata, Bunzo, et al.
Publicado: (1992)

Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells
por: Brouwer, Isabella J., et al.
Publicado: (2020)

The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo
por: Ku, Jin Mo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qb0npgo1qntcn67q2aloar3unn