Cargando…

Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung

LAMP2A and HSC70 are crucial players in chaperone-mediated autophagy (CMA), a targeted, lysosome-dependent protein degradation pathway. Elevated LAMP2A levels, indicative of increased CMA activity, are observed in several malignancies, and CMA downregulation may be exploited therapeutically. We eval...

Descripción completa

Detalles Bibliográficos
Autores principales:	Losmanová, Tereza, Janser, Félice A., Humbert, Magali, Tokarchuk, Igor, Schläfli, Anna M., Neppl, Christina, Schmid, Ralph A., Tschan, Mario P., Langer, Rupert, Berezowska, Sabina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527932/ https://www.ncbi.nlm.nih.gov/pubmed/33029283 http://dx.doi.org/10.1155/2020/8506572

Ejemplares similares

Corrigendum to “Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung”
por: Losmanová, Tereza, et al.
Publicado: (2021)

Chaperone-Mediated Autophagy Markers LAMP2A and HSPA8 in Advanced Non-Small Cell Lung Cancer after Neoadjuvant Therapy
por: Losmanova, Tereza, et al.
Publicado: (2021)

Expression Analysis of Autophagy Related Markers LC3B, p62 and HMGB1 Indicate an Autophagy-Independent Negative Prognostic Impact of High p62 Expression in Pulmonary Squamous Cell Carcinomas
por: Langer, Rupert, et al.
Publicado: (2018)

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas
por: Adams, Olivia, et al.
Publicado: (2016)

Reliable LC3 and p62 Autophagy Marker Detection in Formalin Fixed Paraffin Embedded Human Tissue by Immunohistochemistry
por: Schläfli, A.M., et al.
Publicado: (2015)

Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer
por: Schläfli, Anna M., et al.
Publicado: (2016)

A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
por: Adams, Olivia, et al.
Publicado: (2018)

Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
por: Adams, Olivia, et al.
Publicado: (2019)

ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells
por: Schläfli, Anna M., et al.
Publicado: (2021)

Frequency and Significance of Pathologic Pulmonary Findings in Postmortem Examinations—A Single Center Experience before COVID-19
por: Berezowska, Sabina, et al.
Publicado: (2021)

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells
por: Ryu, Seung W., et al.
Publicado: (2020)

Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells
por: Janser, Félice A., et al.
Publicado: (2018)

Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin
por: Ganguly, Archan, et al.
Publicado: (2017)

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR
por: Baaklini, Imad, et al.
Publicado: (2020)

Quantitative analysis of the interplay between hsc70 and its co-chaperone HspBP1
por: Mahboubi, Hicham, et al.
Publicado: (2015)

Hsc70’s trip to the tip
por: Leslie, Mitch
Publicado: (2015)

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly
por: Xing, Yi, et al.
Publicado: (2010)

Comparative analysis of the anticoagulant activities and immunogenicity of HSC70 and HSC70(TKD) of Haemaphysalis flava
por: Liu, Yu-Ke, et al.
Publicado: (2022)

Hsc70 is required for endocytosis and clathrin function in Drosophila
por: Chang, Henry C., et al.
Publicado: (2002)

A prognostic score for non-small cell lung cancer resected after neoadjuvant therapy in comparison with the tumor-node-metastases classification and major pathological response
por: Zens, Philipp, et al.
Publicado: (2021)

Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1
por: DeGeer, Jonathan, et al.
Publicado: (2015)

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2019)

Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy
por: Srinivasan, Vignesh, et al.
Publicado: (2019)

Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila
por: Zhu, Jun-yi, et al.
Publicado: (2021)

Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy
por: Schnebert, Simon, et al.
Publicado: (2022)

The Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment
por: Niklaus, Nicolas J., et al.
Publicado: (2021)

The Hsc/Hsp70 Co-Chaperone Network Controls Antigen Aggregation and Presentation during Maturation of Professional Antigen Presenting Cells
por: Kettern, Nadja, et al.
Publicado: (2011)

Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP
por: Morey, Trevor M., et al.
Publicado: (2017)

A plant reovirus hijacks the DNAJB12–Hsc70 chaperone complex to promote viral spread in its planthopper vector
por: Liang, Qifu, et al.
Publicado: (2021)

Mechanism and Complex Roles of HSC70 in Viral Infections
por: Wang, Zeng, et al.
Publicado: (2020)

Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70
por: Hong, Zhouping, et al.
Publicado: (2022)

Specialized Hsp70 Chaperone (HscA) Binds Preferentially to the Disordered Form, whereas J-protein (HscB) Binds Preferentially to the Structured Form of the Iron-Sulfur Cluster Scaffold Protein (IscU)
por: Kim, Jin Hae, et al.
Publicado: (2012)

Dominant-Interfering Hsc70 Mutants Disrupt Multiple Stages of the Clathrin-Coated Vesicle Cycle in Vivo
por: Newmyer, Sherri L., et al.
Publicado: (2001)

Serratia marcescens‐S3 inhibits Potato virus Y by activating ubiquitination of molecular chaperone proteins NbHsc70‐2 in Nicotiana benthamiana
por: Ge, Ming, et al.
Publicado: (2021)

Comparison of the 7th and 8th Edition of the UICC/AJCC TNM Staging System in Primary Resected Squamous Cell Carcinomas of the Lung—A Single Center Analysis of 354 Cases
por: Neppl, Christina, et al.
Publicado: (2019)

Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIP
por: Soss, Sarah E., et al.
Publicado: (2015)

Hsp70 Architecture: The Formation of Novel Polymeric Structures of Hsp70.1 and Hsc70 after Proteotoxic Stress
por: Steel, Rohan, et al.
Publicado: (2012)

Similarities and Differences of Hsp70, hsc70, Grp78 and Mortalin as Cancer Biomarkers and Drug Targets
por: Rai, Rajani, et al.
Publicado: (2021)

Insights from the protein sequence and structure analysis of PgHsc70 and OsHsp70 genes
por: Baloji, Gugulothu, et al.
Publicado: (2022)

Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer
por: Niklaus, Monique, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dfhp2kd47a36r04to75lh713t5