High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cells

Using a MLL-AF9 knock-in mouse model, we discovered that consumption of a high-fat diet (HFD) accelerates the risk of developing acute myeloid leukemia (AML). This regimen increases the clusterization of FLT3 within lipid rafts on the cell surface of primitive hematopoietic cells, which overactivate...

Descripción completa

Detalles Bibliográficos
Autores principales: Hermetet, François, Mshaik, Rony, Simonet, John, Callier, Patrick, Delva, Laurent, Quéré, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528010/
https://www.ncbi.nlm.nih.gov/pubmed/32999332
http://dx.doi.org/10.1038/s41598-020-73020-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528010/
https://www.ncbi.nlm.nih.gov/pubmed/32999332
http://dx.doi.org/10.1038/s41598-020-73020-4

Ejemplares similares