Single molecule studies reveal that p53 tetramers dynamically bind response elements containing one or two half sites

The tumor suppressor protein p53 is critical for cell fate decisions, including apoptosis, senescence, and cell cycle arrest. p53 is a tetrameric transcription factor that binds DNA response elements to regulate transcription of target genes. p53 response elements consist of two decameric half-sites...

Descripción completa

Detalles Bibliográficos
Autores principales: Ly, Elina, Kugel, Jennifer F., Goodrich, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528078/
https://www.ncbi.nlm.nih.gov/pubmed/32999415
http://dx.doi.org/10.1038/s41598-020-73234-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528078/
https://www.ncbi.nlm.nih.gov/pubmed/32999415
http://dx.doi.org/10.1038/s41598-020-73234-6

Ejemplares similares