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Single molecule studies reveal that p53 tetramers dynamically bind response elements containing one or two half sites
The tumor suppressor protein p53 is critical for cell fate decisions, including apoptosis, senescence, and cell cycle arrest. p53 is a tetrameric transcription factor that binds DNA response elements to regulate transcription of target genes. p53 response elements consist of two decameric half-sites...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528078/ https://www.ncbi.nlm.nih.gov/pubmed/32999415 http://dx.doi.org/10.1038/s41598-020-73234-6 |