Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth

BACKGROUND: Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of tumor cells could help identify therapies to eliminate these cells. Significan...

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Detalles Bibliográficos
Autores principales: Metz, Ethan P., Wuebben, Erin L., Wilder, Phillip J., Cox, Jesse L., Datta, Kaustubh, Coulter, Donald, Rizzino, Angie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528478/
https://www.ncbi.nlm.nih.gov/pubmed/32998722
http://dx.doi.org/10.1186/s12885-020-07370-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528478/
https://www.ncbi.nlm.nih.gov/pubmed/32998722
http://dx.doi.org/10.1186/s12885-020-07370-7

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