Evolution of resistance to fluoroquinolones by dengue virus serotype 4 provides insight into mechanism of action and consequences for viral fitness

Drugs against flaviviruses such as dengue (DENV) and Zika (ZIKV) virus are urgently needed. We previously demonstrated that three fluoroquinolones, ciprofloxacin, enoxacin, and difloxacin, suppress replication of six flaviviruses. To investigate the barrier to resistance and mechanism(s) of action o...

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Detalles Bibliográficos
Autores principales: Scroggs, Stacey L.P., Gass, Jordan T., Chinnasamy, Ramesh, Widen, Steven G., Azar, Sasha R., Rossi, Shannan L., Arterburn, Jeffrey B., Vasilakis, Nikos, Hanley, Kathryn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528753/
https://www.ncbi.nlm.nih.gov/pubmed/33120225
http://dx.doi.org/10.1016/j.virol.2020.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528753/
https://www.ncbi.nlm.nih.gov/pubmed/33120225
http://dx.doi.org/10.1016/j.virol.2020.09.004

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