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Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice

Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is mediated, in part, by increased levels of inflamma...

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Detalles Bibliográficos
Autores principales: Parks, Eileen E., Logan, Sreemathi, Yeganeh, Alexander, Farley, Julie A., Owen, Daniel B., Sonntag, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529050/
https://www.ncbi.nlm.nih.gov/pubmed/32669383
http://dx.doi.org/10.1194/jlr.RA119000479