Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts

Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiologies and Polygenic Risk Scores (PRS). However, the presence of subtypes within many phenotypes is fr...

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Detalles Bibliográficos
Autores principales: Yuan, Jie, Xing, Henry, Lamy, Alexandre Louis, Lencz, Todd, Pe’er, Itsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529195/
https://www.ncbi.nlm.nih.gov/pubmed/32956347
http://dx.doi.org/10.1371/journal.pgen.1009015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529195/
https://www.ncbi.nlm.nih.gov/pubmed/32956347
http://dx.doi.org/10.1371/journal.pgen.1009015

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