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Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts
Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiologies and Polygenic Risk Scores (PRS). However, the presence of subtypes within many phenotypes is fr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529195/ https://www.ncbi.nlm.nih.gov/pubmed/32956347 http://dx.doi.org/10.1371/journal.pgen.1009015 |