Closely related reovirus lab strains induce opposite expression of RIG-I/IFN-dependent versus -independent host genes, via mechanisms of slow replication versus polymorphisms in dsRNA binding σ3 respectively

The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host relationships and a candidate oncolytic virotherapy. Closely related laboratory strains of T3D, originating from the same ancestral T3D isolate, were recently found to exhibit significantly different oncolytic pr...

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Detalles Bibliográficos
Autores principales: Mohamed, Adil, Konda, Prathyusha, Eaton, Heather E., Gujar, Shashi, Smiley, James R., Shmulevitz, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529228/
https://www.ncbi.nlm.nih.gov/pubmed/32956403
http://dx.doi.org/10.1371/journal.ppat.1008803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529228/
https://www.ncbi.nlm.nih.gov/pubmed/32956403
http://dx.doi.org/10.1371/journal.ppat.1008803

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