Knock in of a hexanucleotide repeat expansion in the C9orf72 gene induces ALS in rats

BACKGROUND: The GGGGCC (G4C2) repeat expansion in the human open reading frame 72 on chromosome 9, C9orf72, is the most common cause of amyotrophic lateral sclerosis (ALS). Studies in transgenic mouse models have linked the pathogenic mechanism of G4C2 repeat expansion to RNA foci or the accumulatio...

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Detalles Bibliográficos
Autores principales: Dong, Wei, Zhang, Li, Sun, Caixian, Gao, Xiang, Guan, Feifei, Li, Jing, Chen, Wei, Ma, Yuanwu, Zhang, Lianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529333/
https://www.ncbi.nlm.nih.gov/pubmed/33024945
http://dx.doi.org/10.1002/ame2.12129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529333/
https://www.ncbi.nlm.nih.gov/pubmed/33024945
http://dx.doi.org/10.1002/ame2.12129

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