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Characterization of t-loop formation by TRF2

T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ. Here we establish that TRF2 alone, in the absence of other shelterin proteins can form t-loops. Mouse and human cel...

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Detalles Bibliográficos
Autores principales: Timashev, Leonid A., De Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529409/
https://www.ncbi.nlm.nih.gov/pubmed/32564646
http://dx.doi.org/10.1080/19491034.2020.1783782