Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

Absence seizures result from 3 to 5 Hz generalized thalamocortical oscillations that depend on highly regulated inhibitory neurotransmission in the thalamus. Efficient reuptake of the inhibitory neurotransmitter GABA is essential, and reuptake failure worsens human seizures. Here, we show that block...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Adam C, Lee, Christine Kyuyoung, Kleiman-Weiner, Max, Truong, Brian, Wang, Megan, Huguenard, John R, Beenhakker, Mark P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529462/
https://www.ncbi.nlm.nih.gov/pubmed/32902384
http://dx.doi.org/10.7554/eLife.59548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529462/
https://www.ncbi.nlm.nih.gov/pubmed/32902384
http://dx.doi.org/10.7554/eLife.59548

Ejemplares similares