CDKN2C-Null Leiomyosarcoma: A Novel, Genomically Distinct Class of TP53/RB1–Wild-Type Tumor With Frequent CIC Genomic Alterations and 1p/19q-Codeletion

PURPOSE: Leiomyosarcoma (LMS) harbors frequent mutations in TP53 and RB1 but few actionable genomic alterations. Here, we searched for recurrent actionable genomic alterations in LMS that occur in the absence of common untreatable oncogenic drivers. METHODS: Tissues from 276,645 unique advanced canc...

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Detalles Bibliográficos
Autores principales: Williams, Erik A., Sharaf, Radwa, Decker, Brennan, Werth, Adrienne J., Toma, Helen, Montesion, Meagan, Sokol, Ethan S., Pavlick, Dean C., Shah, Nikunj, Williams, Kevin Jon, Venstrom, Jeffrey M., Alexander, Brian M., Ross, Jeffrey S., Albacker, Lee A., Lin, Douglas I., Ramkissoon, Shakti H., Elvin, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2020
Materias:
Original Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529542/
https://www.ncbi.nlm.nih.gov/pubmed/33015533
http://dx.doi.org/10.1200/PO.20.00040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529542/
https://www.ncbi.nlm.nih.gov/pubmed/33015533
http://dx.doi.org/10.1200/PO.20.00040

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