Dual Asymmetric Centrifugation Efficiently Produces a Poloxamer-Based Nanoemulsion Gel for Topical Delivery of Pirfenidone

This study used dual asymmetric centrifugation (DAC) to produce a topical vehicle for Pirfenidone (Pf; 5-methyl-1-phenyl-2[1H]-pyridone)—a Food and Drug Administration-approved antifibrotic drug indicated for idiopathic fibrosis treatment. Pf was loaded (8 wt%) in a poloxamer nanoemulsion gel (PNG)...

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Detalles Bibliográficos
Autores principales: Chung, Eugene P., Wells, Adrienne R., Kiamco, Mia Mae, Leung, Kai P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529632/
https://www.ncbi.nlm.nih.gov/pubmed/33006045
http://dx.doi.org/10.1208/s12249-020-01798-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529632/
https://www.ncbi.nlm.nih.gov/pubmed/33006045
http://dx.doi.org/10.1208/s12249-020-01798-7

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