Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathways

Immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide show remarkable anti-tumor activity in multiple myeloma (MM) via directly inhibiting MM cell growth in the bone marrow (BM) microenvironment and promoting immune effector cell function. They are known to bind to the ubiquitin 3 ligase CRBN...

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Detalles Bibliográficos
Autores principales: Hideshima, Teru, Ogiya, Daisuke, Liu, Jiye, Harada, Takeshi, Kurata, Keiji, Bae, Jooeun, Massefski, Walter, Anderson, Kenneth C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529681/
https://www.ncbi.nlm.nih.gov/pubmed/32238854
http://dx.doi.org/10.1038/s41375-020-0809-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529681/
https://www.ncbi.nlm.nih.gov/pubmed/32238854
http://dx.doi.org/10.1038/s41375-020-0809-x

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