STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs

STAT3 transcription factor induces differentiation of naïve T cells into Th17 cells and loss of STAT3 in T cell prevents development of CNS autoimmune diseases. However, function of STAT3 in the B lymphocyte subset is not well understood. In this study, we have generated mice lacking STAT3 in CD19(+...

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Detalles Bibliográficos
Autores principales: Oladipupo, Favour O., Yu, Cheng-Rong, Olumuyide, Ezekiel, Jittaysothorn, Yingyos, Choi, Jin Kyeong, Egwuagu, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529787/
https://www.ncbi.nlm.nih.gov/pubmed/33004854
http://dx.doi.org/10.1038/s41598-020-73093-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529787/
https://www.ncbi.nlm.nih.gov/pubmed/33004854
http://dx.doi.org/10.1038/s41598-020-73093-1

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