Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study

BACKGROUND: Bioinformatically designed mosaic antigens increase the breadth of HIV vaccine-elicited immunity. This study compared the safety, tolerability, and immunogenicity of a newly developed, tetravalent Ad26 vaccine with the previously tested trivalent formulation. METHODS: This randomised, pa...

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Detalles Bibliográficos
Autores principales: Baden, Lindsey R, Stieh, Daniel J, Sarnecki, Michal, Walsh, Stephen R, Tomaras, Georgia D, Kublin, James G, McElrath, M Juliana, Alter, Galit, Ferrari, Guido, Montefiori, David, Mann, Philipp, Nijs, Steven, Callewaert, Katleen, Goepfert, Paul, Edupuganti, Srilatha, Karita, Etienne, Langedijk, Johannes P, Wegmann, Frank, Corey, Lawrence, Pau, Maria G, Barouch, Dan H, Schuitemaker, Hanneke, Tomaka, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529856/
https://www.ncbi.nlm.nih.gov/pubmed/33010242
http://dx.doi.org/10.1016/S2352-3018(20)30229-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529856/
https://www.ncbi.nlm.nih.gov/pubmed/33010242
http://dx.doi.org/10.1016/S2352-3018(20)30229-0

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