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Biosynthesis of medicinal tropane alkaloids in yeast

Tropane alkaloids (TAs) from nightshade plants are neurotransmitter inhibitors used for treating neuromuscular disorders and are classified as essential medicines by the World Health Organization(1,2). Global supply challenges have resulted in frequent drug shortages(3,4). Further supply-chain vulne...

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Detalles Bibliográficos
Autores principales: Srinivasan, Prashanth, Smolke, Christina D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529995/
https://www.ncbi.nlm.nih.gov/pubmed/32879484
http://dx.doi.org/10.1038/s41586-020-2650-9