High-Content Screening of Eukaryotic Kinase Inhibitors Identify CHK2 Inhibitor Activity Against Mycobacterium tuberculosis

A screen of a eukaryotic kinase inhibitor library in an established intracellular infection model identified a set of drug candidates enabling intracellular killing of Mycobacterium tuberculosis (M.tb). Screen validity was confirmed internally by a Z′ = 0.5 and externally by detecting previously rep...

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Detalles Bibliográficos
Autores principales: Shapira, Tirosh, Rankine-Wilson, Leah, Chao, Joseph D., Pichler, Virginia, Rens, Celine, Pfeifer, Tom, Av-Gay, Yossef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530171/
https://www.ncbi.nlm.nih.gov/pubmed/33042061
http://dx.doi.org/10.3389/fmicb.2020.553962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530171/
https://www.ncbi.nlm.nih.gov/pubmed/33042061
http://dx.doi.org/10.3389/fmicb.2020.553962

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