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Statistical properties of Continuous Composite Outcomes: Implications for clinical trial design
Statistical efficiency can be gained in clinical trials by using composites of time-to-event outcomes when the individual component outcomes have low event rates. However, the utility of continuous composite outcome measures is not as clear. Efficiency can be either gained or lost by using a continu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530289/ https://www.ncbi.nlm.nih.gov/pubmed/33024883 http://dx.doi.org/10.1016/j.conctc.2020.100655 |