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IbpB‐bound substrate release in living cells as revealed by unnatural amino acid‐mediated photo‐crosslinking

Small heat shock proteins (sHSPs) are known to bind non‐native substrates and prevent irreversible aggregation in an ATP‐independent manner. However, the dynamic interaction between sHSPs and their substrates in vivo is less studied. Here, by utilizing a genetically incorporated crosslinker, we char...

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Detalles Bibliográficos
Autores principales: Shi, Xiaodong, Ezemaduka, Anastasia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530376/
https://www.ncbi.nlm.nih.gov/pubmed/32812699
http://dx.doi.org/10.1002/2211-5463.12957