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A label‐free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P(1) agonists
Sphingosine‐1 phosphate receptor‐1 (S1P(1)) activation maintains endothelial barrier integrity, whereas S1P(1) desensitization induces peripheral blood lymphopenia. The latter is exploited in the approval and/or late‐stage development of receptor‐desensitizing agents targeting the S1P(1) receptor in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530392/ https://www.ncbi.nlm.nih.gov/pubmed/32810927 http://dx.doi.org/10.1002/2211-5463.12951 |