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A label‐free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P(1) agonists

Sphingosine‐1 phosphate receptor‐1 (S1P(1)) activation maintains endothelial barrier integrity, whereas S1P(1) desensitization induces peripheral blood lymphopenia. The latter is exploited in the approval and/or late‐stage development of receptor‐desensitizing agents targeting the S1P(1) receptor in...

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Detalles Bibliográficos
Autores principales:	Grailhe, Patrick, Boutarfa‐Madec, Asma, Beauverger, Philippe, Janiak, Philip, Parkar, Ashfaq A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530392/ https://www.ncbi.nlm.nih.gov/pubmed/32810927 http://dx.doi.org/10.1002/2211-5463.12951

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