Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids

Inference of causality between gene expression and complex traits using Mendelian randomization (MR) is confounded by pleiotropy and linkage disequilibrium (LD) of gene-expression quantitative trait loci (eQTL). Here, we propose an MR method, MR-link, that accounts for unobserved pleiotropy and LD b...

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Detalles Bibliográficos
Autores principales: van der Graaf, Adriaan, Claringbould, Annique, Rimbert, Antoine, Westra, Harm-Jan, Li, Yang, Wijmenga, Cisca, Sanna, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530717/
https://www.ncbi.nlm.nih.gov/pubmed/33004804
http://dx.doi.org/10.1038/s41467-020-18716-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530717/
https://www.ncbi.nlm.nih.gov/pubmed/33004804
http://dx.doi.org/10.1038/s41467-020-18716-x

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